acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome

MeSH: C536000ORPHA: 903011 Treatment Available

Overview

This syndrome is characterised by the association of acanthosis nigricans, insulin resistance, severe muscle cramps and acral hypertrophy

Available Treatments (1)

DrugFormStatusCountriesLead Time
metformin
oral tablets 500mg/850mg/1000mg, extended-release tablets 500mg/750mgFDA Approved92d

Clinical Presentation

Signs and symptoms associated with acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome, sourced from HPO and Orphanet clinical annotations.

Enlarged kidneyPolycystic ovariesInsulin-resistant diabetes mellitusElevated circulating growth hormone concentrationInsulin resistanceAcanthosis nigricansHirsutismMuscle spasmEnlarged polycystic ovaries

Classification & Codes

MeSH Code

C536000

Orphanet Code

ORPHA:90301
acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome
MeSHC536000
OrphanetORPHA:90301
Treatments1 drug(s)
Symptoms on record9 signs
Statuspublished

Treatment Summary

Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO