Acromegaly
ICD-10: E22.0MeSH: D000172ORPHA: 99725
Overview
Acromegaly is a rare endocrine disorder caused by excessive growth hormone secretion, typically from a pituitary adenoma, occurring after epiphyseal closure. Clinical features include progressive enlargement of hands, feet, and facial features, along with metabolic complications, cardiovascular disease, and increased cancer risk. The estimated prevalence is 40-125 cases per million population, with an annual incidence of 3-4 cases per million.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Acromegaly, sourced from HPO and Orphanet clinical annotations.
Tall statureAmenorrheaCoarse facial featuresMandibular prognathiaIncreased circulating prolactin concentrationElevated circulating growth hormone concentrationHyperhidrosisLarge handsHypertrophic cardiomyopathyLeft ventricular hypertrophyLong footFrontal bossingAccelerated skeletal maturationType II diabetes mellitusPituitary prolactin cell adenomaProportionate tall staturePituitary growth hormone cell adenomaPremature pubarcheIncreased circulating insulin-like growth factor 1 concentrationGalactorrhea
Classification & Codes
ICD-10 Code
E22.0MeSH Code
D000172Orphanet Code
ORPHA:99725Acromegaly
| ICD-10 | E22.0 |
| MeSH | D000172 |
| Orphanet | ORPHA:99725 |
| Treatments | 0 drug(s) |
| Symptoms on record | 20 signs |
| Status | published |
Factual Authority
Last Updated3/21/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO