Acute promyelocytic leukemia
ICD-10: 2A30.0MeSH: D015470ORPHA: 520
Overview
Acute promyelocytic leukemia is a distinct rare subtype of acute myeloid leukemia defined by the PML-RARA fusion, most often from t(15;17). It commonly presents with bleeding, coagulopathy, cytopenias, and marrow failure, and it requires urgent diagnosis because disseminated intravascular coagulation is frequent. Although rare, it is highly treatable, with all-trans retinoic acid and arsenic trioxide forming the core of modern therapy.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Acute promyelocytic leukemia, sourced from HPO and Orphanet clinical annotations.
Gingival bleedingEpistaxisPetechiaeBruising susceptibilityPurpuraMuscle weaknessWeight lossThrombocytopeniaPancytopeniaDecreased total leukocyte countAbnormal bleedingAnemiaFeverAnorexiaVertigoExertional dyspneaDisseminated intravascular coagulationFatigueBone marrow hypercellularityChronic infectionEcchymosisGingival overgrowthDecreased total neutrophil countIncreased total leukocyte countAbdominal painBone painLymphadenopathyStomatitisHypofibrinogenemiaDiffuse alveolar hemorrhageOral cavity bleedingAddictive alcohol useProductive coughHematuriaMetrorrhagiaGangrene
Classification & Codes
ICD-10 Code
2A30.0MeSH Code
D015470Orphanet Code
ORPHA:520Acute promyelocytic leukemia
| ICD-10 | 2A30.0 |
| MeSH | D015470 |
| Orphanet | ORPHA:520 |
| Treatments | 0 drug(s) |
| Symptoms on record | 36 signs |
| Status | published |
Factual Authority
Last Updated7/24/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO