Addison's disease
MeSH: D000224ORPHA: 85138
Overview
adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Addison's disease, sourced from HPO and Orphanet clinical annotations.
Salt cravingType I diabetes mellitusThiamine-responsive megaloblastic anemiaPrimary testicular failureThymomaDiarrheaNausea and vomitingConstipationAbdominal painAnorexiaHypotensionAutoimmunityIncreased circulating ACTH levelFatigueRenal salt wastingIncreased circulating renin concentrationTachycardiaNormocytic anemiaDehydrationHyperuricemiaHyperkalemiaHyponatremiaDecreased circulating aldosterone concentrationHyperkalemic metabolic acidosisAndrogen insufficiencyDecreased urinary potassiumDecreased circulating cortisol levelPrimary adrenal insufficiencyHyperpigmentation of the skinMuscle weaknessFailure to thriveWeight lossAstheniaMalaiseAnti-side-chain cleavage enzyme antibody positivityAnti-steroid 17alpha-hydroxylase antibody positivityAnti-21-hydroxylase antibody positivityDelayed pubertyHypoparathyroidismAdrenal hypoplasiaHashimoto thyroiditisDry skinVitiligoSeizureOrthostatic hypotensionAlopeciaHypoglycemiaSparse axillary hairVertigoCeliac diseaseArthralgiaHypercalcemiaGeneralized bone demineralizationPremature ovarian insufficiencyAdrenal calcificationDecreased female libido
Classification & Codes
MeSH Code
D000224Orphanet Code
ORPHA:85138Addison's disease
| MeSH | D000224 |
| Orphanet | ORPHA:85138 |
| Treatments | 0 drug(s) |
| Symptoms on record | 56 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO