Alexander disease type II
ORPHA: 363722
Overview
Alexander disease type II (AxD type II) is an astrogliopathy and a form of Alexander disease (AxD; see this term) characterized by ataxia, bulbar symptoms, spastic paraparesis, palatal myoclonus, and autonomic symptoms
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Alexander disease type II, sourced from HPO and Orphanet clinical annotations.
Cervical spinal cord atrophyAbnormal medulla oblongata morphologyNystagmusAtaxiaSpasticityDysarthriaHyperreflexiaDysphoniaDysphagiaSpastic paraparesisAbnormal periventricular white matter morphologyUrinary bladder sphincter dysfunctionBabinski signLimb muscle weaknessPeriventricular cystsPalatal tremorAbnormal autonomic nervous system physiologyRigiditySleep disturbanceScoliosis
Classification & Codes
Orphanet Code
ORPHA:363722Alexander disease type II
| Orphanet | ORPHA:363722 |
| Treatments | 0 drug(s) |
| Symptoms on record | 20 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO