Allan-Herndon-Dudley syndrome
MeSH: C537047ORPHA: 59
Overview
congenital disorder of nervous system
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Allan-Herndon-Dudley syndrome, sourced from HPO and Orphanet clinical annotations.
Intellectual disabilityAxial hypotoniaNarrow faceLong faceDelayed speech and language developmentPectus excavatumHypertensionHyperhidrosisAtaxiaSpasticityChoreoathetosisDystoniaHyperreflexiaFailure to thrive in infancyTachycardiaPes planusMyopathic faciesRecurrent respiratory infectionsSleep disturbanceHypokinesiaKyphoscoliosisAbnormality of thyroid physiologySkeletal muscle atrophyAbnormal pyramidal signPes valgusFeeding difficulties in infancyIncreased circulating free T3Brain atrophyDelayed myelinationDelayed ability to walkDecreased body mass indexCryptorchidismMicrocephalyNystagmusSeizureNeonatal hypotoniaBrisk reflexesFlexion contractureDecreased fetal movementAbnormality of extrapyramidal motor functionModerate intellectual disabilityPoor head controlLimb hypertoniaSpastic tetraplegiaGeneralized muscle weaknessBabinski signShort statureProlonged neonatal jaundiceAnkle clonusSmall for gestational agePolyhydramniosPremature birthMacrocephaly at birthDyskinesia
Classification & Codes
MeSH Code
C537047Orphanet Code
ORPHA:59Allan-Herndon-Dudley syndrome
| MeSH | C537047 |
| Orphanet | ORPHA:59 |
| Treatments | 0 drug(s) |
| Symptoms on record | 54 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO