Alpers' disease
ORPHA: 726
Overview
cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has symptom convulsions
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Alpers' disease, sourced from HPO and Orphanet clinical annotations.
MicrocephalyAbnormality of the eyeAbnormality of visionBlindnessAtaxiaHypotoniaSpasticityComaGlobal developmental delayChoreoathetosisAreflexiaMyoclonusBilateral tonic-clonic seizureProgressive spasticitySpastic paraparesisDevelopmental regressionParaparesisFocal-onset seizureAbnormality of movement
Classification & Codes
Orphanet Code
ORPHA:726Alpers' disease
| Orphanet | ORPHA:726 |
| Treatments | 0 drug(s) |
| Symptoms on record | 19 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO