alpha-2-plasmin inhibitor deficiency
MeSH: C537777ORPHA: 79
Overview
hemorrhagic disease that has material basis in mutation in the PLI gene. It is characterized by a hemorrhagic tendency presenting from childhood with prolonged bleeding and ecchymoses following minor trauma and spontaneous bleeding episodes
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with alpha-2-plasmin inhibitor deficiency, sourced from HPO and Orphanet clinical annotations.
Persistent bleeding after traumaJoint hemorrhageHematuriaAbnormal bleedingHemothoraxIntramuscular hematomaReduced euglobulin clot lysis timeGingival bleedingBruising susceptibilityIntracranial hemorrhageBone painAbnormal umbilical stump bleeding
Classification & Codes
MeSH Code
C537777Orphanet Code
ORPHA:79alpha-2-plasmin inhibitor deficiency
| MeSH | C537777 |
| Orphanet | ORPHA:79 |
| Treatments | 0 drug(s) |
| Symptoms on record | 12 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO