alpha-N-acetylgalactosaminidase deficiency type 3

ORPHA: 792811 Treatment Available

Overview

Alpha-N-acetylgalactosaminidase (NAGA) deficiency type 3 is a rare clinically heterogeneous type of NAGA deficiency (see this term) with developmental, neurologic and psychiatric manifestations presenting at an intermediate age

Available Treatments (1)

DrugFormStatusCountriesLead Time
laronidase
Orphan Cold Chain
IV infusion, 0.58 mg/mLFDA Approved, EMA Approved814d

Clinical Presentation

Signs and symptoms associated with alpha-N-acetylgalactosaminidase deficiency type 3, sourced from HPO and Orphanet clinical annotations.

StrabismusCataractAutismIntellectual disabilitySeizureGlobal developmental delayHypertrophic cardiomyopathyHepatomegaly

Classification & Codes

Orphanet Code

ORPHA:79281
alpha-N-acetylgalactosaminidase deficiency type 3
OrphanetORPHA:79281
Treatments1 drug(s)
Symptoms on record8 signs
Statuspublished

Treatment Summary

Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO