amyotrophic lateral sclerosis
MeSH: D000690ORPHA: 803
Overview
rare neurodegenerative disease with amyotrophy and progressive paralysis
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with amyotrophic lateral sclerosis, sourced from HPO and Orphanet clinical annotations.
Amyotrophic lateral sclerosisNeurodegenerationGeneralized muscle weaknessMotor neuron atrophyXerostomiaAtypical behaviorEmotional labilityDepressionAnxietySpasticityDysarthriaHyperreflexiaDysphoniaWeight lossDysphagiaDyspneaDroolingFasciculationsRespiratory failureSkeletal muscle atrophyMuscle spasmParalysisUpper limb muscle weaknessBabinski signDistal amyotrophyLower limb muscle weaknessProgressive distal muscular atrophyFatigueTongue atrophyPainFatigable weakness of bulbar musclesFatigable weakness of swallowing musclesFatigable weakness of respiratory musclesAbnormality on pulmonary function testingHoffmann signCognitive impairmentTongue fasciculationsFrontotemporal dementiaSpastic paraparesisSleep disturbanceLanguage impairmentSteppage gaitCachexiaFoot dorsiflexor weaknessOrthopneaJaw hyperreflexiaLaryngospasm
Classification & Codes
MeSH Code
D000690Orphanet Code
ORPHA:803amyotrophic lateral sclerosis
| MeSH | D000690 |
| Orphanet | ORPHA:803 |
| Treatments | 0 drug(s) |
| Symptoms on record | 47 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO