amyotrophic lateral sclerosis and frontotemporal dementia
MeSH: C566288ORPHA: 275872
Overview
clinic-pathological entity that can be framed within frontotemporal dementia
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with amyotrophic lateral sclerosis and frontotemporal dementia, sourced from HPO and Orphanet clinical annotations.
Abnormal lower motor neuron morphologyAtypical behaviorDepressionHallucinationsApathyDysarthriaParkinsonismDysphagiaAbnormality of extrapyramidal motor functionProgressive cerebellar ataxiaGliosisApraxiaTetraparesisDegeneration of the lateral corticospinal tractsParaparesisDyscalculiaDistal muscle weaknessGeneralized amyotrophyProximal muscle weaknessNeuronal loss in the cerebral cortexWeakness due to upper motor neuron dysfunctionSupranuclear gaze palsyDisinhibitionHyporeflexiaBulbar palsyGlobal brain atrophyMutismFasciculationsBabinski signAbnormal mitochondrial morphologyBilateral sensorineural hearing impairmentPerseverative thoughtPtosisAbnormal upper motor neuron morphologyFrontotemporal dementia
Classification & Codes
MeSH Code
C566288Orphanet Code
ORPHA:275872amyotrophic lateral sclerosis and frontotemporal dementia
| MeSH | C566288 |
| Orphanet | ORPHA:275872 |
| Treatments | 0 drug(s) |
| Symptoms on record | 35 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO