antisynthetase syndrome
MeSH: C537778ORPHA: 81
Overview
human disease
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with antisynthetase syndrome, sourced from HPO and Orphanet clinical annotations.
Muscle weaknessRespiratory insufficiencyPulmonary fibrosisAutoimmunityMyalgiaAbnormal pulmonary interstitial morphologyCoughMyositisChest painXerostomiaEdemaKeratoconjunctivitis siccaHypotoniaArthritisFeverDyspneaArthralgiaElevated circulating creatine kinase concentrationEMG abnormalityRaynaud phenomenonAnti-threonyl-tRNA synthetase antibody positivityAnti-alanyl-tRNA synthetase antibody positivityAnti-glycyl tRNA-synthetase antibody positivityAnti-aminoacyl-tRNA synthetase antibody positivityAnti-isoleucyl tRNA-synthetase antibody positivityAnti-phenylalanyl tRNA synthetase antibody positivityAnti-tyrosyl-tRNA synthetase antibody positivityAnti-asparaginyl-tRNA synthetase antibody positivityAnti-histidyl tRNA synthetase antibody positivityAnti-cytosolic-5-nucleotidase-1A antibody positivityLack of skin elasticitySkin rashPruritusJoint dislocationAbnormality of the voiceAortic regurgitationDysphagiaPulmonary arterial hypertensionRecurrent respiratory infectionsNeoplasmMyocarditisTelangiectasia of the skinMechanic's handsHiker's feet
Classification & Codes
MeSH Code
C537778Orphanet Code
ORPHA:81antisynthetase syndrome
| MeSH | C537778 |
| Orphanet | ORPHA:81 |
| Treatments | 0 drug(s) |
| Symptoms on record | 44 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO