autoimmune lymphoproliferative syndrome

MeSH: D056735ORPHA: 3261

Overview

Human disease

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with autoimmune lymphoproliferative syndrome, sourced from HPO and Orphanet clinical annotations.

SplenomegalyLymphadenopathyChronic noninfectious lymphadenopathyAutoimmunityBruising susceptibilityAutoimmune hemolytic anemiaAbnormal bleedingAutoimmune neutropeniaHypersplenismAutoimmune thrombocytopeniaHepatomegalyElevated double-negative T cell proportionIncreased circulating IgG concentrationIncreased total B cell countIncreased circulating immunoglobulin concentrationAbnormal T cell apoptosisIncreased circulating interleukin 10 concentrationGlomerulonephritisUrticariaIncreased total eosinophil countDecreased total lymphocyte countReticulocytosisVasculitisDecreased specific anti-polysaccharide antibody levelDecreased circulating total IgMRheumatoid factor positiveIncreased circulating IgE concentrationIncreased circulating IgA concentrationAntineutrophil antibody positivityAntinuclear antibody positivityAntiphospholipid antibody positivityDecreased circulating IgG concentrationCoombs-positive hemolytic anemiaHepatitisHodgkin lymphomaT-cell lymphomaB-cell lymphomaNon-Hodgkin lymphomaBurkitt lymphomaAbnormal CD4+ T cell subset proportionAbnormal CD8+ T cell proportionIncreased circulating interleukin 18 concentrationAbnormal circulating vitamin B12 concentrationThyroiditisIncreased total lymphocyte countElevated circulating vitamin B12 concentrationElevated circulating sFASL concentrationRenal insufficiencyUveitisThyroid adenomaSeizureArthritisHepatocellular carcinomaHydrops fetalisPulmonary infiltratesPulmonary fibrosisHeadacheColitisBasal cell carcinomaSystemic lupus erythematosusThyroid carcinomaGastritisBone marrow hypocellularityNeoplasm of the skinPremature ovarian insufficiencyFibroadenoma of the breastRecurrent aphthous stomatitisPanniculitisBone marrow hypercellularityNeoplasm of the tongueAbnormal circulating interleukin concentrationDecreased CD4+ T cell proportion

Classification & Codes

MeSH Code

D056735

Orphanet Code

ORPHA:3261
autoimmune lymphoproliferative syndrome
MeSHD056735
OrphanetORPHA:3261
Treatments0 drug(s)
Symptoms on record72 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO