autosomal dominant non-syndromic intellectual disability 32

ORPHA: 457193

Overview

autosomal dominant non-syndromic intellectual disability that has material basis in an autosomal dominant mutation of KAT6A on chromosome 8p11.21

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with autosomal dominant non-syndromic intellectual disability 32, sourced from HPO and Orphanet clinical annotations.

Thin upper lip vermilionMicrocephalyNarrow foreheadProminent nasal bridgeBroad nasal tipGlobal developmental delayNeonatal hypotoniaAbnormal facial shapePoor speechSevere intellectual disabilityEpicanthusMicroretrognathiaPosteriorly rotated earsStrabismusPtosisSeizurePlagiocephalyCraniosynostosisGrowth delayVentricular septal defectAtrial septal defectPatent ductus arteriosusGastroesophageal refluxNeonatal respiratory distressDownturned corners of mouthMuscle stiffnessShort statureFeeding difficultiesCerebral visual impairmentCryptorchidismHydronephrosisCleft palateOptic atrophyBrachydactylyDystoniaLaryngomalaciaIntestinal malrotationPreauricular pitLacrimal duct stenosis

Classification & Codes

Orphanet Code

ORPHA:457193
autosomal dominant non-syndromic intellectual disability 32
OrphanetORPHA:457193
Treatments0 drug(s)
Symptoms on record39 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO