bilateral generalized polymicrogyria
ORPHA: 208447
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with bilateral generalized polymicrogyria, sourced from HPO and Orphanet clinical annotations.
Delayed gross motor developmentProfound global developmental delayDelayed ability to walkAtypical behaviorMotor stereotypySpasticityGeneralized-onset seizureMutismSpastic tetraplegiaAxial hypotoniaSevere intellectual disabilityFeeding difficultiesAbnormality of movementCerebral visual impairmentMicrocephalyAutistic behaviorMild intellectual disabilityDystoniaGrowth delayGastroesophageal refluxBilateral tonic-clonic seizureHypoplasia of the corpus callosumGeneralized myoclonic seizureStatus epilepticusProfound intellectual disabilityModerate intellectual disabilitySleep disturbanceShort statureImpaired masticationLateral ventricle dilatationParoxysmal dyskinesiaDiffuse white matter abnormalitiesFocal-onset seizureTotal ophthalmoplegiaOculogyric crisisGeneralized tonic seizureAtonic seizureFocal emotional seizure with laughingTypical absence seizureFocal motor seizureSevere global developmental delayInfantile spasmsWidened subarachnoid spaceEyelid myoclonusAbnormal hippocampus morphologyHypoplastic hippocampusNasogastric tube feedingDyskinesiaSelf-injurious behaviorOral-pharyngeal dysphagiaDevelopmental regression
Classification & Codes
Orphanet Code
ORPHA:208447bilateral generalized polymicrogyria
| Orphanet | ORPHA:208447 |
| Treatments | 0 drug(s) |
| Symptoms on record | 51 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO