Castleman Disease
ICD-10: D47.Z2MeSH: D005871
Overview
Castleman disease is a rare lymphoproliferative disorder characterized by non-malignant lymph node enlargement and systemic inflammatory symptoms. Unicentric Castleman disease involves a single lymph node region, while multicentric Castleman disease (MCD) affects multiple regions and is often associated with HHV-8 infection or idiopathic hypercytokinemia driven by IL-6. The estimated incidence is approximately 4,500-5,000 new cases annually in the United States.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Classification & Codes
ICD-10 Code
D47.Z2MeSH Code
D005871Castleman Disease
| ICD-10 | D47.Z2 |
| MeSH | D005871 |
| Treatments | 0 drug(s) |
| Status | published |
Factual Authority
Last Updated3/21/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO