Castleman's disease

ICD-10: D47.Z2MeSH: D005871ORPHA: 160

Overview

lymphoproliferative syndrome characterized by one or more enlarged lymph nodes containing cells with hyaline-vascular, plasmacytic, or mixed appearance microscopically

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Castleman's disease, sourced from HPO and Orphanet clinical annotations.

LymphadenopathyWeight lossAnemiaAbdominal painFollicular hyperplasiaElevated erythrocyte sedimentation rateElevated circulating C-reactive protein concentrationFatigueConstitutional symptomIncreased circulating interleukin 6 concentrationMediastinal lymphadenopathyJaundiceNausea and vomitingAbdominal distentionGeneralized lymphadenopathyAbnormality of the gastrointestinal tractCoughDecreased mean corpuscular volumeFlank painAbdominal massRenal insufficiencyHematuriaRestrictive cardiomyopathyThrombocytopeniaDyspneaIntestinal obstructionUreteral obstructionMyelofibrosisAnasarca

Classification & Codes

ICD-10 Code

D47.Z2

MeSH Code

D005871

Orphanet Code

ORPHA:160
Castleman's disease
ICD-10D47.Z2
MeSHD005871
OrphanetORPHA:160
Treatments0 drug(s)
Symptoms on record29 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO