catastrophic antiphospholipid syndrome
ORPHA: 464343
Overview
human disease
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with catastrophic antiphospholipid syndrome, sourced from HPO and Orphanet clinical annotations.
Angina pectorisChoreaPulmonary arterial hypertensionGastrointestinal infarctionsAcute encephalopathyAvascular necrosisMyocarditisRetinal arterial occlusionGangreneAbnormal jugular vein morphologyAntiphospholipid antibody positivityAbnormal thrombosisMicroangiopathic hemolytic anemiaDeep venous thrombosisPeripheral thrombosisArthralgiaArterial thrombosisCoombs-positive hemolytic anemiaVenous thrombosisAbnormal circulating cytokine concentrationAnticardiolipin IgG antibody positivityAnti-beta 2 glycoprotein I antibody positivityAbnormality of the nervous systemCutis marmorataSeizureStrokeArthritisAbnormal heart valve morphologyMyocardial infarctionThrombocytopeniaMigrainePulmonary embolismTransient ischemic attackSuperficial thrombophlebitisSystemic lupus erythematosusAnticardiolipin IgM antibody positivityArterial occlusionLupus anticoagulantAbnormal heart valve physiologyAnti-phosphatidyl ethanolamine antibody positivityAnti-phosphatidyl choline antibody positivityAnti-phosphatidyl glycerol antibody positivityAnti-phosphatidyl inositol antibody positivityAnti-phosphatidyl serine antibody positivityAnti-annexin-V antibody positivityAmaurosis fugaxSkin ulcerAbnormality of the kidneyDementia
Classification & Codes
Orphanet Code
ORPHA:464343catastrophic antiphospholipid syndrome
| Orphanet | ORPHA:464343 |
| Treatments | 0 drug(s) |
| Symptoms on record | 49 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO