Catel–Manzke syndrome
MeSH: C535347ORPHA: 1388
Overview
Catel-Manzke syndrome is a rare bone disease characterized by bilateral hyperphalangy and clinodactyly of the index finger typically in association with Pierre Robin sequence (see this term) comprising micrognathia, cleft palate and glossoptosis
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Catel–Manzke syndrome, sourced from HPO and Orphanet clinical annotations.
Camptodactyly of fingerGlossoptosisCleft palateMalar flatteningMicrognathiaFailure to thriveClinodactyly of the 5th fingerAbnormal epiphysis morphologyFull cheeksChronic otitis mediaJoint stiffnessVentricular septal defectHighly arched eyebrowScoliosisShort statureAbnormal cardiovascular system morphologyHypertelorismPectus excavatumAtrial septal defectVentriculomegalyRadial deviation of the 2nd fingerOral synechiaMetatarsus valgusPosteriorly rotated earsJoint hypermobility
Classification & Codes
MeSH Code
C535347Orphanet Code
ORPHA:1388Catel–Manzke syndrome
| MeSH | C535347 |
| Orphanet | ORPHA:1388 |
| Treatments | 0 drug(s) |
| Symptoms on record | 25 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO