chromosome Xp21 deletion syndrome

ORPHA: 261476

Overview

Human disease

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with chromosome Xp21 deletion syndrome, sourced from HPO and Orphanet clinical annotations.

Hypogonadotropic hypogonadismEverted lower lip vermilionHypertelorismRecurrent otitis mediaStrabismusHypermetropiaEsotropiaGlobal developmental delayAdrenal insufficiencyOsteoporosisIntellectual disabilitySeizureSpasticityComaAgenesis of corpus callosumNeonatal hypotoniaConfusionGrowth delayKetoacidosisNausea and vomitingHypertriglyceridemiaMyopathyDecreased muscle massElevated circulating creatine kinase concentrationCalf muscle hypertrophyExercise-induced myalgiaIncreased muscle fatiguabilityReduced bone mineral densityApneic episodes in infancyPrimary adrenal insufficiencyFinger clinodactylyJoint hypermobility

Classification & Codes

Orphanet Code

ORPHA:261476
chromosome Xp21 deletion syndrome
OrphanetORPHA:261476
Treatments0 drug(s)
Symptoms on record32 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO