chronic progressive external ophthalmoplegia

MeSH: D017246ORPHA: 663

Overview

human disease

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with chronic progressive external ophthalmoplegia, sourced from HPO and Orphanet clinical annotations.

Progressive external ophthalmoplegiaMuscle abnormality related to mitochondrial dysfunctionPtosisHypothyroidismBrisk reflexesRestrictive ventilatory defectIncreased circulating lactate concentrationRespiratory insufficiency due to muscle weaknessRagged-red muscle fibersAxial muscle weaknessEMG abnormalityMildly elevated creatine kinaseAbnormal mitochondria in muscle tissueProgressive proximal muscle weaknessDepressionMild intellectual disability

Classification & Codes

MeSH Code

D017246

Orphanet Code

ORPHA:663
chronic progressive external ophthalmoplegia
MeSHD017246
OrphanetORPHA:663
Treatments0 drug(s)
Symptoms on record16 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO
chronic progressive external ophthalmoplegia | OrphanDrug