cloverleaf skull-multiple congenital anomalies syndrome
MeSH: C564611ORPHA: 93267
Overview
This newly described syndrome is characterized by cloverleaf skull, limb anomalies, facial dysmorphism and multiple congenital anomalies
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with cloverleaf skull-multiple congenital anomalies syndrome, sourced from HPO and Orphanet clinical annotations.
Ambiguous genitaliaLarge fontanellesHypertelorismShort philtrumMicrognathiaLow-set earsWide nasal bridgeShort neckCataractMicrophthalmiaAbnormal rib morphologyNarrow chestAbnormal clavicle morphologyPlatyspondylyAbnormal metaphysis morphologyAgenesis of corpus callosumOmphaloceleVentricular septal defectFrontal bossingCloverleaf skullPlatybasiaDownturned corners of mouthDecreased skull ossificationAbnormal epiphysis morphologyBowing of the long bonesRhizomeliaProximal placement of thumb
Classification & Codes
MeSH Code
C564611Orphanet Code
ORPHA:93267cloverleaf skull-multiple congenital anomalies syndrome
| MeSH | C564611 |
| Orphanet | ORPHA:93267 |
| Treatments | 0 drug(s) |
| Symptoms on record | 27 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO