combined deficiency of factor V and factor VIII
ORPHA: 35909
Overview
Combined deficiency of factor V and factor VIII is an inherited bleeding disorder due to the reduction in activity and antigen levels of both factor V (FV) and factor VIII (FVIII) and characterized by mild-to-moderate bleeding symptoms
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with combined deficiency of factor V and factor VIII, sourced from HPO and Orphanet clinical annotations.
Reduced factor VIII activityReduced coagulation factor V activityProlonged partial thromboplastin timeProlonged prothrombin timeGingival bleedingEpistaxisBruising susceptibilityProlonged bleeding after dental extractionBleeding with minor or no traumaProlonged bleeding following circumcisionMenorrhagiaHematuriaIntracranial hemorrhageGastrointestinal hemorrhageProlonged bleeding after surgeryJoint hemorrhageHyperuricemiaHyperlipidemia
Classification & Codes
Orphanet Code
ORPHA:35909combined deficiency of factor V and factor VIII
| Orphanet | ORPHA:35909 |
| Treatments | 0 drug(s) |
| Symptoms on record | 18 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO