combined oxidative phosphorylation deficiency 29

ORPHA: 478029

Overview

human disease

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with combined oxidative phosphorylation deficiency 29, sourced from HPO and Orphanet clinical annotations.

RetinopathyOptic neuropathyBilateral tonic-clonic seizureIncreased circulating lactate concentrationNeurodegenerationGlobal brain atrophyIncoordinationSubependymal cystsIncreased CSF lactateGastrointestinal dysmotilityIncreased CSF protein concentrationMyoclonic spasmsAbnormal muscle toneSevere global developmental delayPrimary microcephalyDecreased activity of mitochondrial complex IDecreased activity of mitochondrial complex IIIAbnormal autonomic nervous system physiologyDelayed myelinationGastrojejunal tube feeding in infancyAxonal degenerationDiffuse cerebellar atrophy

Classification & Codes

Orphanet Code

ORPHA:478029
combined oxidative phosphorylation deficiency 29
OrphanetORPHA:478029
Treatments0 drug(s)
Symptoms on record22 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO