congenital hypothyroidism due to transplacental passage of maternal TSH-binding inhibitory antibodies
ORPHA: 95715
Overview
Congenital hypothyroidism due to transplacental passage of maternal thyroid-stimulating hormone (TSH)-binding inhibitory antibodies is a type of transient congenital hypothyroidism (see this term), a thyroid hormone deficiency that is not permanent
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with congenital hypothyroidism due to transplacental passage of maternal TSH-binding inhibitory antibodies, sourced from HPO and Orphanet clinical annotations.
Autoimmune antibody positivityWide anterior fontanelDry skinHyporeflexiaUmbilical herniaConstipationAbnormality of thyroid physiologyFeeding difficultiesDecreased thyroid-stimulating hormone levelReduced radioactive iodine uptakeDecreased circulating T4 concentrationExcessive daytime somnolenceCoarse facial featuresNeonatal hypotoniaConjugated hyperbilirubinemiaProlonged neonatal jaundiceAnti-thyroid peroxidase antibody positivityAbnormal circulating thyroglobulin concentrationMoon facies
Classification & Codes
Orphanet Code
ORPHA:95715congenital hypothyroidism due to transplacental passage of maternal TSH-binding inhibitory antibodies
| Orphanet | ORPHA:95715 |
| Treatments | 0 drug(s) |
| Symptoms on record | 19 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO