Crane-Heise syndrome

MeSH: C536452ORPHA: 1512

Contents

1. Overview
2. Available Treatments
3. Clinical Presentation
4. Classification & Codes

Overview

Crane-Heise syndrome is a very rare syndrome characterized by poorly mineralized calvarium, facial dysmorphism, vertebral abnormalities and absent clavicles

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with Crane-Heise syndrome, sourced from HPO and Orphanet clinical annotations.

Cleft palateHypertelorismMicrognathiaAnteverted naresHypoplastic scapulaeIntrauterine growth retardationTalipes equinovarusDecreased skull ossificationDepressed nasal bridgeAplastic clavicleCryptorchidismJoint stiffnessToe syndactylyFinger syndactylyShort distal phalanx of fingerAbnormally ossified vertebraeVentriculomegalyAplasia/Hypoplasia of the corpus callosumHypoplasia of penisPosteriorly rotated ears

Classification & Codes

MeSH Code

C536452

Orphanet Code

ORPHA:1512

Crane-Heise syndrome

MeSH	`C536452`
Orphanet	`ORPHA:1512`
Treatments	0 drug(s)
Symptoms on record	20 signs
Status	published

Factual Authority

Last Updated3/20/2026

Clinical DataHPO · Orphanet

Drug DataFDA · EMA · CDSCO