Creutzfeldt-Jakob disease
MeSH: D007562ORPHA: 282166
Overview
degenerative neurological disorder
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Creutzfeldt-Jakob disease, sourced from HPO and Orphanet clinical annotations.
Abnormality of visionSupranuclear gaze palsyNystagmusEmotional labilityDepressionDementiaShort attention spanIrritabilityAnxietyApathyPersonality changesSeizureConfusionMuscle weaknessMyoclonusTremorSlurred speechGait ataxiaBradykinesiaProgressive cerebellar ataxiaGlobal brain atrophyClumsinessStroke-like episodeAstrocytosisSpastic dysarthriaNeuronal loss in central nervous systemBabinski signLoss of facial expressionDiffuse spongiform leukoencephalopathyCentral nervous system degenerationProgressive forgetfulnessProgressive extrapyramidal muscular rigidityFocal T2 hyperintense basal ganglia lesionAbnormal pyramidal signEEG with persistent abnormal rhythmic activitySpastic hemiparesisAbnormal autonomic nervous system physiologyAkinetic mutismPoor visual behavior for ageSenile plaquesInsomniaExcessive daytime somnolenceHallucinationsDelusionChoreaIncreased CSF protein concentrationAbnormal pupillary functionVestibular nystagmusAmyloidosis of peripheral nervesTrigeminal neuralgia
Classification & Codes
MeSH Code
D007562Orphanet Code
ORPHA:282166Creutzfeldt-Jakob disease
| MeSH | D007562 |
| Orphanet | ORPHA:282166 |
| Treatments | 0 drug(s) |
| Symptoms on record | 50 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO