Cushing's disease
ICD-10: E24.0ORPHA: 96253
Overview
disease related to the anterior pituitary
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Cushing's disease, sourced from HPO and Orphanet clinical annotations.
OsteoporosisHyperpigmentation of the skinThin skinBruising susceptibilityHirsutismPlethoraPoor wound healingAcneStriae distensaeMuscle weaknessAbnormality of the cardiovascular systemDecreased total lymphocyte countTruncal obesityIncreased total leukocyte countImmunodeficiencyIncreased circulating ACTH levelIncreased body weightProximal amyotrophyAdrenal hyperplasiaIntra-oral hyperpigmentationAbdominal obesityCapillary fragilityDorsocervical fat padIncreased circulating cortisol levelParadoxical increased cortisol secretion on dexamethasone suppression testPituitary corticotropic cell adenomaIncreased urinary cortisol levelAmenorrheaAtypical behaviorEmotional labilityDiabetes mellitusHypertensionDecreased total eosinophil countImpaired glucose toleranceMoon faciesDepressionPsychotic episodesSecondary amenorrheaOligomenorrheaPurpuraStrokeMyocardial infarctionAbnormality of the respiratory systemSparse scalp hairHeadacheMemory impairmentLarge sella turcicaVertebral compression fractureRecurrent cutaneous fungal infectionsFlushingEcchymosisSuicidal ideationAbnormal libidoLivedo reticularisSkin ulcerPsychosisDementiaVisual field defectOptic nerve compressionPedal edemaAvascular necrosisParanoiaPanic attackFatiguable weakness of proximal limb muscles
Classification & Codes
ICD-10 Code
E24.0Orphanet Code
ORPHA:96253Cushing's disease
| ICD-10 | E24.0 |
| Orphanet | ORPHA:96253 |
| Treatments | 0 drug(s) |
| Symptoms on record | 64 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO