DEND syndrome
MeSH: C565253ORPHA: 79134
Overview
DEND syndrome is a very rare, generally severe form of neonatal diabetes mellitus (NDM, see this term) characterized by a triad of developmental delay, epilepsy, and neonatal diabetes
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with DEND syndrome, sourced from HPO and Orphanet clinical annotations.
HyperglycemiaElevated hemoglobin A1cSeizureMuscle weaknessAxial hypotoniaMild global developmental delayLong philtrumAnteverted naresBilateral ptosisDehydrationVomitingHypsarrhythmiaDownturned corners of mouthShort noseProminent metopic ridgePeripheral neuropathyThickened earsClinodactyly of the 4th finger
Classification & Codes
MeSH Code
C565253Orphanet Code
ORPHA:79134DEND syndrome
| MeSH | C565253 |
| Orphanet | ORPHA:79134 |
| Treatments | 0 drug(s) |
| Symptoms on record | 18 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO