dermatomyositis

ICD-10: M33.033.0-M33.133.1MeSH: D003882ORPHA: 221

Overview

myositis that results in inflammation located in muscle or located in skin where a skin rash is often seen prior to the onset of muscle weakness

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with dermatomyositis, sourced from HPO and Orphanet clinical annotations.

Weight lossRespiratory insufficiencyRecurrent respiratory infectionsPulmonary fibrosisDiffuse reticular or finely nodular infiltrationsRespiratory insufficiency due to muscle weaknessArthralgiaElevated circulating hepatic transaminase concentrationElevated circulating creatine kinase concentrationEMG: myopathic abnormalitiesAbnormal pulmonary interstitial morphologyAbnormal hair quantityFatigueElevated circulating aldolase concentrationIncreased circulating lactate dehydrogenase concentrationGottron's papulesShawl signAnti-SUMO-activating enzyme subunit 1 antibody positivityAnti-SUMO-activating enzyme subunit 2 antibody positivityHeliotrope rashMyositisPapuleSkin ulcerCutaneous photosensitivityPoikilodermaAlopeciaDysphoniaMyocardial infarctionAbnormal eyelid morphologyEdemaAutoimmunityLimb-girdle muscle weaknessMyalgiaEMG abnormalityProximal muscle weaknessInflammatory myopathyErythemaPeriorbital edemaChondrocalcinosisDry skinSkin rashPruritusFacial erythemaAcrocyanosisHypotoniaArthritisAbnormal nail morphologyPericarditisAbnormal eosinophil morphologyFeverDysphagiaPulmonary arterial hypertensionVasculitisNeoplasmLymphomaBreast carcinomaAplasia/Hypoplasia of the skinFeeding difficulties in infancyArrhythmiaSinus tachycardiaMyocarditisV-signLung adenocarcinomaRaynaud phenomenonAnti-MDA5 antibody positivityAnti-Mi2 antibody positivityAnti-transcription intermediary factor-1gamma antibody positivityAnti-SUMO-activating enzyme antibody positivityAnti-nuclear matrix protein-2 antibody positivityAnti-histidyl tRNA synthetase antibody positivityTelangiectasia of the skinCellulitisGastrointestinal stroma tumorGangreneGottron signHolster signPalmar hyperkeratosisMuscle weaknessGottron's sign

Classification & Codes

ICD-10 Code

M33.033.0-M33.133.1

MeSH Code

D003882

Orphanet Code

ORPHA:221
dermatomyositis
ICD-10M33.033.0-M33.133.1
MeSHD003882
OrphanetORPHA:221
Treatments0 drug(s)
Symptoms on record79 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO