diffuse scleroderma
MeSH: D045743ORPHA: 220393
Overview
variant of systemic scleroderma characterized by sclerosis of the skin, Raynaud phenomenon, and organ involvement, including pulmonary fibrosis, renal disease, and gastrointestinal tract involvement
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with diffuse scleroderma, sourced from HPO and Orphanet clinical annotations.
Renal insufficiencyXerostomiaCarious teethAbnormality of the skinMuscle weaknessArthritisFlexion contractureCongestive heart failureDysphagiaNausea and vomitingGastroesophageal refluxMalabsorptionPulmonary arterial hypertensionDyspneaPulmonary infiltratesPulmonary fibrosisOsteolysisArthralgiaAutoimmunityDyspareuniaAbnormal bowel soundsOliguriaTelangiectasia of the skinHypertensive crisisNarrow foramen obturatoriumSkin ulcer
Classification & Codes
MeSH Code
D045743Orphanet Code
ORPHA:220393diffuse scleroderma
| MeSH | D045743 |
| Orphanet | ORPHA:220393 |
| Treatments | 0 drug(s) |
| Symptoms on record | 26 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO