early-onset autosomal dominant Alzheimer disease
ORPHA: 1020
Overview
Early-onset autosomal dominant Alzheimer disease (EOAD) is a progressive dementia with reduction of cognitive functions. EOAD presents the same phenotype as sporadic Alzheimer disease (AD) but has an early age of onset, usually before 60 years old.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with early-onset autosomal dominant Alzheimer disease, sourced from HPO and Orphanet clinical annotations.
AgitationDementiaHallucinationsSeizureHypertoniaConfusionParkinsonismMyoclonusCerebral cortical atrophyNeurofibrillary tanglesMemory impairmentLanguage impairmentDeposits immunoreactive to beta-amyloid proteinAbnormal social behaviorNeurodevelopmental abnormalityDisinhibitionAbnormality of visionOculomotor apraxiaIntellectual disabilityAtaxiaApraxiaAphasiaFinger agnosiaDysgraphiaAbnormality of mental functionSemantic dementia
Classification & Codes
Orphanet Code
ORPHA:1020early-onset autosomal dominant Alzheimer disease
| Orphanet | ORPHA:1020 |
| Treatments | 0 drug(s) |
| Symptoms on record | 26 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO