familial hypocalciuric hypercalcemia

ORPHA: 405

Overview

hypercalcemia characterized byautosomal dominant inheritance with elevation of serum calcium levels and decreased urinary calcium excretion

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with familial hypocalciuric hypercalcemia, sourced from HPO and Orphanet clinical annotations.

HypercalcemiaHypocalciuriaReduced ratio of renal calcium clearance to creatinine clearanceParathormone-independent increased renal tubular calcium reabsorptionOsteomalaciaRenal hypophosphatemiaChondrocalcinosisNausea and vomitingHeadacheEpisodic abdominal painHypermagnesemiaPeptic ulcerFatigueHypomagnesiuriaNephrolithiasisPancreatitisHypocalcemic seizuresAutoimmunityLipoma

Classification & Codes

Orphanet Code

ORPHA:405
familial hypocalciuric hypercalcemia
OrphanetORPHA:405
Treatments0 drug(s)
Symptoms on record19 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO