familial infantile gigantism
ORPHA: 300373
Overview
human disease
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with familial infantile gigantism, sourced from HPO and Orphanet clinical annotations.
Tall statureElevated circulating growth hormone concentrationIncreased circulating prolactin concentrationAbnormal pituitary gland morphologyIncreased circulating insulin-like growth factor 1 concentrationCoarse facial featuresHyperhidrosisThickened skinPolyphagiaPituitary adenomaAbnormal oral glucose toleranceFasting hyperinsulinemiaSleep apneaAbnormal optic chiasm morphologySnoringDecreased thyroid-stimulating hormone levelIncreased body mass indexHypogonadismDiastemaDelayed pubertyDiabetes insipidusAbnormality of the skeletal systemAcanthosis nigricansVisual field defectLarge handsSeizureAtaxiaAbnormality of the cardiovascular systemLong footHeadacheAbdominal distentionAdrenocorticotropic hormone deficiencyEnlarged pituitary glandHypopituitarismAbnormality of the nervous systemIntellectual disability
Classification & Codes
Orphanet Code
ORPHA:300373familial infantile gigantism
| Orphanet | ORPHA:300373 |
| Treatments | 0 drug(s) |
| Symptoms on record | 36 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO