fatal familial insomnia
ICD-10: A81.981.9MeSH: D034062ORPHA: 466
Overview
Prion disease of the human brain
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with fatal familial insomnia, sourced from HPO and Orphanet clinical annotations.
DementiaMyoclonusAbnormal autonomic nervous system physiologyInsomniaEmotional labilityDepressionHallucinationsAnxietyHypertensionHyperhidrosisAtaxiaDysarthriaTachycardiaDysphagiaAbnormality of extrapyramidal motor functionLaryngeal stridorSleep-wake cycle disturbanceEpiphoraSleep apneaThalamic hypometabolism in FDG PETAbnormally slow thought processShort term memory impairmentCognitive impairmentReduced attention regulationShort REM sleepDiplopiaWeight lossFeverConstipationLoss of speechIncreased circulating cortisol levelAbnormal pyramidal signAbnormal pineal melatonin secretionArterial hypertensionHallucinationPhobiaAgrypnia excitataAgeingPanic attackGeneralized anxiety disorder
Classification & Codes
ICD-10 Code
A81.981.9MeSH Code
D034062Orphanet Code
ORPHA:466fatal familial insomnia
| ICD-10 | A81.981.9 |
| MeSH | D034062 |
| Orphanet | ORPHA:466 |
| Treatments | 0 drug(s) |
| Symptoms on record | 40 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO