fibrous dysplasia of bone
ICD-10: K10.8MeSH: D005357ORPHA: 249
Overview
bone remodeling disease that results in the destruction of normal bone and replacing it with fibrous bone tissue
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with fibrous dysplasia of bone, sourced from HPO and Orphanet clinical annotations.
Abnormal humerus morphologyFibrous dysplasia of the bonesAbnormal skull morphologyOsteolysisAbnormal bone structureAbnormal axial skeleton morphologyAbnormality of limbsAbnormal mandible morphologyAbnormal maxilla morphologyHypophosphatemiaBone painRicketsThin bony cortexPathologic fractureAbnormal femur morphologyElevated circulating alkaline phosphatase concentrationCortical irregularityBowing of the long bonesPatchy reduction of bone mineral densityAbnormal zygomatic bone morphologyAbnormal facial skeleton morphologyAntalgic gaitAbnormal rib morphologyAbnormal clavicle morphologyScoliosisAbnormal parietal bone morphologyOsteomalaciaCoxa varaAbnormal morphology of the radiusAbnormal tibia morphologyAbnormality of the cervical spineFunctional motor deficitShort statureIrregularly spaced teethAbnormal temporal bone morphologyAbnormal occipital bone morphologyAbnormal morphology of ulnaAbnormal pelvis bone morphologyLower limb asymmetryAbnormal lumbar spine morphologyAbnormal frontal bone morphologyAbnormality of the sphenoid sinusOvarian cystHearing impairmentVisual lossAbnormality of the endocrine systemDiabetes mellitusHyperthyroidismElevated circulating growth hormone concentrationOsteosarcomaThyroid carcinomaHypercalcemiaIncreased circulating cortisol levelParesthesiaLarge cafe-au-lait macules with irregular marginsMultiple cafe-au-lait spotsPrecocious puberty in femalesHyperpituitarismTesticular neoplasmCutaneous myxomaNeoplasm of the breastGait disturbance
Classification & Codes
ICD-10 Code
K10.8MeSH Code
D005357Orphanet Code
ORPHA:249fibrous dysplasia of bone
| ICD-10 | K10.8 |
| MeSH | D005357 |
| Orphanet | ORPHA:249 |
| Treatments | 0 drug(s) |
| Symptoms on record | 62 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO