gamma chain deficiency
ICD-10: D80.0MeSH: D053632ORPHA: 276
Overview
immunodeficiency disorder in which the body produces very few T cells and NK cells
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with gamma chain deficiency, sourced from HPO and Orphanet clinical annotations.
Decreased CD4+ T cell proportionDecreased total lymphocyte countRecurrent feverPneumoniaAbnormal circulating immunoglobulin concentrationDecreased mitogen-induced T-cell proliferationDecreased naive T cell proportionReduced total natural killer cell countSkin rashDiarrheaRecurrent bacterial infectionsDecreased circulating IgA concentrationDecreased circulating IgG concentrationRecurrent opportunistic infectionsCoughAbnormally low T cell receptor excision circle levelDecreased total T cell countSepsisFailure to thriveChronic mucocutaneous candidiasisLymph node hypoplasiaRecurrent herpesRecurrent Haemophilus influenzae infectionsRecurrent bacterial skin infectionsSevere recurrent varicellaChronic oral candidiasisRecurrent cutaneous fungal infectionsAbsent tonsilsJaundiceHepatomegalyLymphomaIncreased circulating IgG concentrationLymphoproliferative disorder
Classification & Codes
ICD-10 Code
D80.0MeSH Code
D053632Orphanet Code
ORPHA:276gamma chain deficiency
| ICD-10 | D80.0 |
| MeSH | D053632 |
| Orphanet | ORPHA:276 |
| Treatments | 0 drug(s) |
| Symptoms on record | 33 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO