gigantism
ICD-10: E22.0MeSH: D005877ORPHA: 99725
Overview
human disease which causes the body to grow abnormally large
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with gigantism, sourced from HPO and Orphanet clinical annotations.
Tall statureAmenorrheaCoarse facial featuresMandibular prognathiaIncreased circulating prolactin concentrationElevated circulating growth hormone concentrationHyperhidrosisLarge handsHypertrophic cardiomyopathyLeft ventricular hypertrophyLong footFrontal bossingAccelerated skeletal maturationType II diabetes mellitusPituitary prolactin cell adenomaProportionate tall staturePituitary growth hormone cell adenomaPremature pubarcheIncreased circulating insulin-like growth factor 1 concentrationGalactorrhea
Classification & Codes
ICD-10 Code
E22.0MeSH Code
D005877Orphanet Code
ORPHA:99725gigantism
| ICD-10 | E22.0 |
| MeSH | D005877 |
| Orphanet | ORPHA:99725 |
| Treatments | 0 drug(s) |
| Symptoms on record | 20 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO