Gorham's disease
MeSH: D010015ORPHA: 73
Overview
syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with Gorham's disease, sourced from HPO and Orphanet clinical annotations.
OsteolysisElevated alkaline phosphatase of bone originPatchy reduction of bone mineral densityTorticollisOsteopeniaEdemaBone painAbnormal calvaria morphologyAbnormality of the cervical spineFunctional motor deficitImpaired masticationCortical irregularityOsteolysis involving bones of the lower limbsAbnormality of the temporomandibular jointAbnormality of the internal auditory canalAbnormal facial skeleton morphologyAbnormal bone ossificationAbnormal occipital bone morphologyRhinorrheaOsteolysis involving bones of the upper limbsLymphangiomaMandibular painMastoiditisHearing impairmentAbnormal finger morphologyPleural effusionPathologic fractureAbnormal femur morphologyChiari type I malformationHemangiomatosisAbnormality of the thoracic cavityAbnormal ethmoid bone morphologyMeningitisSpinal cord compressionOsteomyelitisAbnormal pelvis bone morphology
Classification & Codes
MeSH Code
D010015Orphanet Code
ORPHA:73Gorham's disease
| MeSH | D010015 |
| Orphanet | ORPHA:73 |
| Treatments | 0 drug(s) |
| Symptoms on record | 36 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO