GRFoma
ORPHA: 97261
Overview
6cm and approximately 1/3 have metastasized at the time of diagnosis. It often co-occurs with Zollinger-Ellison syndrome or multiple endocrine neoplasia type 1 (MEN 1; see these terms).
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with GRFoma, sourced from HPO and Orphanet clinical annotations.
Elevated circulating growth hormone concentrationCoarse facial featuresAbnormal abdomen morphologyWeight lossDiarrheaNausea and vomitingConstipationAnorexiaZollinger-Ellison syndromeHepatomegalyEpisodic abdominal painNeoplasm of the pancreasIncreased circulating cortisol levelPoor appetitePalmoplantar hyperhidrosisHypoactive bowel soundsNeoplasm of the lungAbnormality of the thyroid glandIncreased circulating gonadotropin levelIncreased circulating prolactin concentrationSubcutaneous lipomaIntermittent jaundiceCholelithiasisIntrahepatic cholestasisAscitesGastrointestinal hemorrhagePituitary adenomaParathyroid adenomaHypercalcemiaIntestinal obstructionIntestinal carcinoidPrimary hyperparathyroidismAdrenocortical adenomaExtrahepatic cholestasisLack of bowel soundsNeoplasm of the small intestinePheochromocytomaNeoplasm of the thymus
Classification & Codes
Orphanet Code
ORPHA:97261GRFoma
| Orphanet | ORPHA:97261 |
| Treatments | 0 drug(s) |
| Symptoms on record | 38 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO