hereditary sensory and autonomic neuropathy type 1
ORPHA: 36386
Overview
hereditary sensory neuropathy characterized by slowly progressing, prominent, predominantly distal sensory loss and autonomic disturbances with juvenile or adult onset and autosomal dominant inheritance
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with hereditary sensory and autonomic neuropathy type 1, sourced from HPO and Orphanet clinical annotations.
Inability to walkOsteomyelitisPathologic fractureNeuropathic arthropathyDistal amyotrophyMotor axonal neuropathyCoughEMG: slow motor conductionMuscle weaknessGait imbalanceAbnormality of the autonomic nervous systemDistal sensory impairmentDecreased amplitude of sensory action potentialsImpaired ability to dress oneselfHyperkeratosisPenetrating foot ulcersPoor wound healingDistal muscle weaknessSteppage gaitImpaired distal tactile sensationPain insensitivityHypohidrosis or hyperhidrosisFoot dorsiflexor weaknessLimb painImpaired temperature sensationTrophic changes related to painSkin ulcerHearing impairmentGastroesophageal reflux
Classification & Codes
Orphanet Code
ORPHA:36386hereditary sensory and autonomic neuropathy type 1
| Orphanet | ORPHA:36386 |
| Treatments | 0 drug(s) |
| Symptoms on record | 29 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO