hereditary spastic paraplegia 15
MeSH: C536642ORPHA: 100996
Overview
hereditary spastic paraplegia that has material basis in mutation in the ZFYVE26 gene on chromosome 14q24.1
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with hereditary spastic paraplegia 15, sourced from HPO and Orphanet clinical annotations.
Hypoplasia of the corpus callosumFunctional abnormality of the bladderPigmentary retinopathyNystagmusIntellectual disabilitySpasticitySpastic paraplegiaDysarthriaGait disturbanceAbnormal cerebellum morphologyMuscle weaknessLower limb spasticityAbnormality of extrapyramidal motor functionLower limb hyperreflexiaAbnormal cerebral white matter morphologyPeripheral axonal neuropathyUpper limb muscle weaknessBabinski signUpper limb spasticityPseudobulbar paralysisDemyelinating peripheral neuropathyLeg muscle stiffnessRetinal flecksYellow/white retinal lesionDeep cerebral white matter hyperintensitiesCognitive impairmentAbnormality of eye movementAtypical behaviorDementiaDiabetes mellitusSaccadic smooth pursuit interruptionsSeizureSpecific learning disabilityPes cavusFrontotemporal dementiaHand tremorImpaired vibratory sensationDistal amyotrophy
Classification & Codes
MeSH Code
C536642Orphanet Code
ORPHA:100996hereditary spastic paraplegia 15
| MeSH | C536642 |
| Orphanet | ORPHA:100996 |
| Treatments | 0 drug(s) |
| Symptoms on record | 38 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO