hereditary spastic paraplegia 28
MeSH: C563732ORPHA: 101008
Overview
hereditary spastic paraplegia that has material basis in mutation in the DDHD1 gene on chromosome 14q22
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with hereditary spastic paraplegia 28, sourced from HPO and Orphanet clinical annotations.
HyperreflexiaBabinski signPes cavusLower limb spasticityRigiditySpastic gaitPostural instabilityUnsteady gaitScoliosisAbolished vibration sensePain insensitivityLower limb muscle weaknessImpaired tactile sensation
Classification & Codes
MeSH Code
C563732Orphanet Code
ORPHA:101008hereditary spastic paraplegia 28
| MeSH | C563732 |
| Orphanet | ORPHA:101008 |
| Treatments | 0 drug(s) |
| Symptoms on record | 13 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO