hereditary spastic paraplegia 31
MeSH: C565210ORPHA: 101011
Overview
30 years). In some cases, it can present as a complex phenotype with additional associated manifestations including peripheral neuropathy, bulbar palsy (with dysarthria and dysphagia), distal amyotrophy, and impaired distal vibration sense.
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with hereditary spastic paraplegia 31, sourced from HPO and Orphanet clinical annotations.
Gait disturbanceBrisk reflexesSpastic gaitProximal lower limb muscle weaknessHypertoniaPes cavusLower limb hyperreflexiaDistal sensory impairmentUpper limb hyperreflexiaProximal lower limb amyotrophyDifficulty runningImpaired proprioceptionDysarthriaSpastic tetraparesisDysphagiaBulbar signsHand muscle weakness
Classification & Codes
MeSH Code
C565210Orphanet Code
ORPHA:101011hereditary spastic paraplegia 31
| MeSH | C565210 |
| Orphanet | ORPHA:101011 |
| Treatments | 0 drug(s) |
| Symptoms on record | 17 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO