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hereditary spastic paraplegia 38

MeSH: C567349ORPHA: 171617

Contents

  1. 1. Overview
  2. 2. Available Treatments
  3. 3. Clinical Presentation
  4. 4. Classification & Codes

Overview

hereditary spastic paraplegia that has material basis in variation in the chromosome region 4p16-p15

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with hereditary spastic paraplegia 38, sourced from HPO and Orphanet clinical annotations.

First dorsal interossei muscle atrophyThenar muscle weaknessEMG abnormalityAmyotrophy of ankle musculatureDistal lower limb muscle weaknessSpinal cord lesionImpaired vibration sensation in the lower limbsFrontotemporal cerebral atrophyFoot dorsiflexor weaknessCognitive impairmentHyperreflexiaPes cavusLower limb spasticitySpastic gaitDegeneration of the lateral corticospinal tractsThenar muscle atrophyBabinski signProgressive spastic paraplegiaFirst dorsal interossei muscle weakness

Classification & Codes

MeSH Code

C567349

Orphanet Code

ORPHA:171617
hereditary spastic paraplegia 38
MeSHC567349
OrphanetORPHA:171617
Treatments0 drug(s)
Symptoms on record19 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO