hereditary spastic paraplegia 3A
MeSH: C536864ORPHA: 100984
Overview
hereditary spastic paraplegia that is characterized by lower limb weakness and spasticity that is generally non-progressive or extremely slow and has material basis in mutation in the ATL1 gene on chromosome 14q22
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with hereditary spastic paraplegia 3A, sourced from HPO and Orphanet clinical annotations.
Lower limb spasticityLower limb hyperreflexiaBabinski signDistal lower limb muscle weaknessGait disturbanceSpastic gaitDistal lower limb amyotrophyAnkle clonusUrinary urgencyMotor delayImpaired vibratory sensationPeripheral neuropathyTip-toe gaitDysarthriaGrowth delayRigidityBradykinesiaFrequent fallsLower limb hypertoniaHyperesthesia
Classification & Codes
MeSH Code
C536864Orphanet Code
ORPHA:100984hereditary spastic paraplegia 3A
| MeSH | C536864 |
| Orphanet | ORPHA:100984 |
| Treatments | 0 drug(s) |
| Symptoms on record | 20 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO