hereditary spastic paraplegia 6
MeSH: C536866ORPHA: 100988
Overview
hereditary spastic paraplegia that is usually characterized by rapidly progressive and severe spastic paraplegia and has material basis in mutation in the NIPA1 gene on chromosome 15q11.2
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with hereditary spastic paraplegia 6, sourced from HPO and Orphanet clinical annotations.
Spastic paraplegiaGait disturbanceLower limb spasticityLower limb hyperreflexiaImpaired vibratory sensationBabinski signPes cavusBilateral tonic-clonic seizureSkeletal muscle atrophyLimited hip movementLimitation of movement at anklesUrinary incontinencePostural tremor
Classification & Codes
MeSH Code
C536866Orphanet Code
ORPHA:100988hereditary spastic paraplegia 6
| MeSH | C536866 |
| Orphanet | ORPHA:100988 |
| Treatments | 0 drug(s) |
| Symptoms on record | 13 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO