hereditary spastic paraplegia 7
ORPHA: 99013
Overview
hereditary spastic paraplegia that is characterized by slowly progressive onset, usually between 18-60 years of age, and generally more severe spasticity and has material basis in mutation in the SPG7 gene on chromosome 16q24
Available Treatments (0)
No treatments linked yet
Clinical trials or compassionate use may be available — consult a specialist.
Clinical Presentation
Signs and symptoms associated with hereditary spastic paraplegia 7, sourced from HPO and Orphanet clinical annotations.
Spastic gaitUrinary urgencySupranuclear gaze palsyNystagmusOptic atrophyCerebellar atrophyHypernasal speechImpaired vibration sensation in the lower limbsLower limb hyperreflexiaRagged-red muscle fibersSomatic sensory dysfunctionBabinski signLower limb hypertoniaAttention deficit hyperactivity disorderSlowed slurred speechAbnormal pyramidal signLower limb muscle weaknessAbnormal mitochondrial morphologyAbnormality of mental functionOptic disc pallorDysarthriaPes cavusCerebral cortical atrophyAbnormal cerebral white matter morphologyScoliosisUpper limb muscle weaknessSpecific learning disabilityDysphagiaMemory impairmentLower limb pain
Classification & Codes
Orphanet Code
ORPHA:99013hereditary spastic paraplegia 7
| Orphanet | ORPHA:99013 |
| Treatments | 0 drug(s) |
| Symptoms on record | 30 signs |
| Status | published |
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO