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hereditary spherocytosis

MeSH: D013103ORPHA: 822

Contents

  1. 1. Overview
  2. 2. Available Treatments
  3. 3. Clinical Presentation
  4. 4. Classification & Codes

Overview

congenital hemolytic anemia characterized by the production of red blood cells with a sphere shape, rather than the normal biconcave disk shape

Available Treatments (0)

No treatments linked yet

Clinical trials or compassionate use may be available — consult a specialist.

Clinical Presentation

Signs and symptoms associated with hereditary spherocytosis, sourced from HPO and Orphanet clinical annotations.

Increased red cell osmotic fragilityJaundicePallorCholelithiasisMuscle weaknessSplenomegalyAnemiaReticulocytosisHepatomegalyHyperbilirubinemiaSpherocytosisSpontaneous hemolytic crisesHypofibrinogenemiaIncreased mean corpuscular hemoglobin concentrationHypercoagulabilityAtaxiaRestrictive cardiomyopathyFeverExtramedullary hematopoiesisAbdominal painMyalgiaChillsMaculopapular exanthemaGrowth delayGoutAbdominal distentionSkin ulcer

Classification & Codes

MeSH Code

D013103

Orphanet Code

ORPHA:822
hereditary spherocytosis
MeSHD013103
OrphanetORPHA:822
Treatments0 drug(s)
Symptoms on record27 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO