hyperinsulinism due to HNF4A deficiency

ORPHA: 263455

Available Treatments (0)

No treatments linked yet

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Clinical Presentation

Signs and symptoms associated with hyperinsulinism due to HNF4A deficiency, sourced from HPO and Orphanet clinical annotations.

ProteinuriaAgitationHyperinsulinemic hypoglycemiaHyperinsulinemiaHyperhidrosisPallorIntellectual disabilitySeizureLethargyComaNeonatal hypotoniaTremorHepatomegalyLarge for gestational ageTachycardiaHypoketotic hypoglycemiaRenal Fanconi syndromeNeonatal hypoglycemiaVomitingDiarrheaDrowsinessProgressive neurologic deteriorationElevated circulating hepatic transaminase concentrationGlycosuriaElevated circulating alkaline phosphatase concentrationFasting hypoglycemiaIncreased body weightAbnormal circulating fatty-acid concentrationPancreatic islet-cell hyperplasiaHypophosphatemic ricketsMetabolic ketoacidosisIncreased hepatic glycogen contentFatigue

Classification & Codes

Orphanet Code

ORPHA:263455
hyperinsulinism due to HNF4A deficiency
OrphanetORPHA:263455
Treatments0 drug(s)
Symptoms on record33 signs
Statuspublished
Factual Authority
Last Updated3/20/2026
Clinical DataHPO · Orphanet
Drug DataFDA · EMA · CDSCO